[Survival rate of patients with esophageal squamous cell carcinoma]

Background and Objective: Squamous carcinoma accounts for the majority of esophageal carcinoma worldwide. This study was done to evaluate the survival rate of patients with esophageal cancer in Iran

Methods: This historical cohort study was carried outon 105 patients with esophageal squamous cell carcinoma whom admitted to Firoozgar hospital in Tehran, Iran during 2009-14. Patients with esophageal squamous cell carcinoma were treated with chemoradiation either with or without surgery

Results: The mean age of patients was 63 years. Frequency of esophageal cancer in both sexes in the age group 51-60 years was higher than other groups. 5-year survival in patients with esophageal cancer treated with chemoradiation without surgery was 9.5% and in patients treated with chemoradiation with surgery was 31.7% [P<0.05]. One-year, three-year and five-year survival rate in patients were treated with chemoradiation with or without surgery was 68.5%, 38% and 22.8%, respectively

Conclusion: The survival rate of patients with esophageal cancer is very low, but the treatment with chemoradiation with surgery can increase life expectancy of patients

[ correlation between serum C-reactive protein and staging of gastric and colon cancers in the patients reffered to firoozgar hospital from march 2010 to august 2011]

C - reactive protein [CRP] is an acute-phase plasma protein that can be used as a marker of activation of the immune system. In response to several inflammatory reactions, the concentration of CRP increases and recently have been applicated as a cancer detector in some studies. We aimed to evaluate the relation between CRP level and the staging and grading of gastric and colon malignancies that are the most common gastrointestinal cancers. In this analytic cross sectional study, 100 patients with gastric and colon cancer referred to Firoozgar hospital from march 2010 to august 2011, were recruited. The diagnosis of cancer was confirmed with multiple biopsies and pathologic study. The exclusion criteria were as follow being febrile or having any clinical evidence of infection, diabetes mellitus, cardiovascular disease, inflammatory bowel disease and autoimmune disease via history and record of the patients. The stage and grade of cancers were determined by two expert pathologists. A 5 cc blood sample was taken from anticobital vein of each patient before any intervention such as surgery, chemotherapy and/or radiotherapy was done and CRP quantitative levels were assessed by ELISA technique. CRP level more than 5 mg/dl was assumed as abnormal. Correlation between CRP and Staging, grading and the location of tumor [gastric and colon malignancies] and the type of tumor [adenocarcinoma and large cell lymphoma] was evaluated. There was no significant correlation between CRP level and the type of tumor [p=0.32] or location of the tumor [p=0.83].A significantly positive correlation was seen between CRP level and the stage of gastric and colon cancers [p=0.02] as well as CRP level and the grade of these tumors [p=0.03]. CRP blood level correlates with the staging and grading of the GI cancer and the level of CRP rises as the stage and grade of the tumor developes

[ comparative study of an experimental model of tendon healing process between healthy rats and streptozotocin induced-diabetic rats by a biomechanical evaluating method]

The aim of the present investigation was to compare the healing process of repaired Achilles tendons of healthy rats and streptozotocin induced diabetic [STZ-D] rats by evaluating strength and toughness of repaired tendons via tensiometrical test. 14 healthy male adult rat were divided into control [n=6] and experimental rats [n=8]. Type 1 diabetes was induced in experimental rats by an injection of 55 mg/kg STZ intraperitoneally. Control rats were received distilled water. Blood Sugar of all rats was recorded after seven days. Animals of experimental group that failed to develop average blood glucose concentration greater than 250mg/dc were excluded from the study. Right Achilles tendon of all rats was transected completely 30 days after STZ injection. Repairing Achilles tendons were extracted and were submitted to a tensiometerical examination10 days after surgery. Data were compared by student t test. Independent sample t test analysis showed that Young's modulus of elasticity [18.5 +/- 12.1MPa/mm] and stress high load [3.04 +/- 1.38, MPa/mm] of control group were significantly higher than those of experimental group [2.5 +/- 2 and 0.975 +/- 0.269 respectively], [p=0.003 and p=0.004 respectively]. It is concluded that induction of type one diabetes by STZ in rats after 30 days reduced significantly tensiometrical parameters of repairing Achilles tendon in comparison with control rats